• Biotechnology

Laboratory of Applied Biochemistry

Main Research Theme
Investigation of primary metabolic pathway specifically operating in pathogens 　Exploring new antibiotics specific to pathogens 　Biosynthetic engineering for efficient production of useful natural products 　Characterization of novel enzymes 　Mechanistic study of newly identified enzymes
Research Field
Natural product chemistry 　Biosynthetic engineering 　Biochemistry 　Genetic engineering
Keyword
Antibiotics 　Biosynthesis 　Metabolism 　Enzymes

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PI Yasushi Ogasawara　Professor

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Research

Our group is currently working on several research areas including characterization of novel enzymatic reactions and biosynthetic engineering. Using chemical and biological approaches, we study “enzyme chemistry” by uncovering unprecedented enzymes involved in diverse biological processes including the formation of bacterial cell wall, biosynthesis of natural products. We also focus on bioproduction of useful and high-value natural products by “biosynthetic engineering”. In addition, we search for new antibiotics that specifically kill pathogenic bacteria by making use of differences in metabolic pathways between useful bacteria and pathogenic bacteria.

Member

  • Yasushi Ogasawara
    Professor
    Research Field
    Natural product chemistry, biochemistry
  • Yasuharu Satoh
    Assistant Professor
    Research Field
    Biochemical engineering, synthetic biology

Main Research Achievements

  • W. Xiao, Y. Satoh, Y. Ogasawara, T. Dairi. ChemBioChem 23, e202100705 (2022).
  • X. Li, R. Shimaya, T. Dairi, W-c. Chang, Y. Ogasawara. Angew. Chem. Int. Ed. 61, e202113189 (2022).
  • Z. Feng, Y. Ogasawara, T. Dairi. Chem. Sci. 12, 2567-2574 (2021).
  • T. Kamide, S. Takusagawa, N. Tanaka, Y. Ogasawara, Y. Kawano, I. Ohtsu, Y. Satoh, T. Dairi. J. Agric. Food Chem. 68, 6390-6394 (2020).
  • Y. Ogasawara, M. Shigematsu, S. Sato, H. Kato, T. Dairi. Org. Lett. 21, 3972-3975 (2019).
  • S. Hayashi, M. Naka, K. Ikeuchi, M. Otsuka, K. Kobayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, T. Ujihara, T. Dairi. Angew. Chem. Int. Ed. 58, 6605-6610 (2019).
  • S. Hayashi, Y. Satoh, Y. Ogasawara, C. Maruyama, Y. Hamano, T. Ujihara, T. Dairi. Angew. Chem. Int. Ed. 58, 2326-2330 (2019).
  • R. Feng, Y. Satoh, Y. Ogasawara, T. Yoshimura, T. Dairi. J. Am. Chem. Soc. 139, 4243-4245 (2017).
  • J. Kawata, T. Naoe, Y. Ogasawara, T. Dairi. Angew. Chem. Int. Ed. 56, 2026-2029 (2017).
  • M. Noike, T. Matsui, K. Ooya, I. Sasaki, S. Ohtaki, Y. Hamano, C. Maruyama, J. Ishikawa, Y. Satoh, H. Ito, H. Morita, T. Dairi. Nat. Chem. Biol., 11, 71-76 (2015).
  • T. Hiratsuka, K. Furihata, J. Ishikawa, H. Yamashita, N. Itoh, H. Seto, T. Dairi. Science, 321, 1670-1673 (2008).

Contact

yogasawa(at)eng.hokudai.ac.jp

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