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PI Manabu Tokeshi　Professor

PI message

What if we scale down traditional chemistry experiments with beakers and flasks? It is natural that the amount of sample and reagent is reduced, but there are various other merits. Microfluidic devices also enable experiments that cannot be achieved with beakers and flasks. Our laboratory is working on the development of microfluidic devices that meet the needs of society, such as medical diagnosis, environmental analysis, food analysis, drug discovery, and drug delivery systems.

Research

We are developing analysis/diagnosis/synthesis systems using microfluidic devices. For example, cancer diagnosis with just one drop of blood, on-site inspection in the field and on-site analysis systems that can analyze and diagnose anyone and anywhere by combining a smartphone and a paper-based device. We are also developing microfluidic devices that enable the production of lipid nanoparticles applied to COVID19 vaccines and the crystal structure analysis of proteins that are the basis of drug discovery. We are promoting research aimed at social implementation of microsystems and microfluidic devices.

Member

• Manabu Tokeshi

  Professor
• Masatoshi Maeki

  Associate Professor
• Akihiko Ishida

  Assistant Professor
• Mitsue Hibino

  Assistant Professor

Main Research Achievements

• K. Nishiyama, R. Mizukami, S. Kuki, A. Ishida, J. Chiba, H. Kido, M. Maeki, H. Tani, M. Tokeshi, Biosens. Bioelectron., 198, 113832 (2022).
  DOI: 10.1016/j.bios.2021.113832
• K. Nishiyama, K. Takahashi, M. Fukuyama, M. Kasuya, A. Imai, T. Usukura, N. Maishi, M. Maeki, A. Ishida, H. Tani, K. Hida, K. Shigemura, A. Hibara, M. Tokeshi, Biosens. Bioelectron., 190, 113414 (2021).
  DOI: 10.1016/j.bios.2021.113414
• T. Komatsu, R. Maeda, M. Maeki, A. Ishida, H. Tani, M. Tokeshi, ACS Sens., 6, 1097 (2021).
  DOI: 10.1021/acssensors.0c02367
• T. Komatsu, R. R. Gabatino, H. Hofileña, M. Maeki, A. Ishida, H. Tani, M. Tokeshi, J. Chem. Edu., 98, 3050 (2021).
  DOI: 10.1021/acs.jchemed.1c00100
• N. Kimura, M. Maeki, A. Ishida, H. Tani, M. Tokeshi, ACS Appl. Bio Mater., 4, 1783 (2021).
  DOI: 10.1021/acsabm.0c01519
• M. Maeki, S. Ito, R. Takeda, G. Ueno, A. Ishida, H. Tani, M. Yamamoto, M. Tokeshi, Chem. Sci., 11, 9072 (2020).
  DOI: 10.1039/D0SC02117B
• K. Nishiyama, Y. Takeda, M. Maeki, A. Ishida, H. Tani, K. Shigemura, A. Hibara, Y. Yonezawa, K. Imai, H. Ogawa, M. Tokeshi, Sens. Actuators B, 316, 128160 (2020).
  DOI:10.1016/j.snb.2020.128160
• N. Kimura, M. Maeki, Y. Sato, A. Ishida, H. Tani, H. Harashima, M. Tokeshi, ACS Appl. Mater. Interfaces, 12, 34011 (2020).
  DOI: 10.1021/acsami.0c05489
• T. Komatsu, M. Maeki, A. Ishida, H. Tani, M. Tokeshi, ACS Sens., 5, 1287 (2020).
  DOI: 10.1021/acssensors.9b02218
• O. Wakao, K. Satou, A. Nakamura, P. A. Galkina, K. Nishiyama, K. Sumiyoshi, F. Kurosawa, M. Maeki, A. Ishida, H. Tani, M. A. Proskurnin, K. Shigemura, A. Hibara, M. Tokeshi, Lab Chip, 19, 2581 (2019):
  DOI: 10.1039/C9LC00256A

Contact

tokeshi(at)eng.hokudai.ac.jp